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Moreover, the complex Gel/(REG NG/LY) is formed by TGF-β inhibitor LY3200882 (LY) encapsulated in ROS-responsive nanogels and homogeneously dispersed with regorafenib (REG) in a thermosensitive hydrogel can not only reduce the recruitment of TAMs and MDSCs and promote macrophages polarization from M2 to M1, but also increase the infiltration of CD8 + T cells into tumors thereby effectively inhibiting tumor growth and metastasis (213)