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[DOI] [PubMed] [Google Scholar] 36.Casiglia E, Bongiovi S, Paleari CD, et al

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Conversely, during prolonged intra-portal hypoinsulinemia (e.g., malnutrition, anorexia nervosa, and T1D), IGFBP-1 levels increase several-fold (7), leading to the increased complex formation between IGF-I and IGFBP-1 and clear reductions in free IGF-I (“brake” effect) ( Figure 2 )