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Approval status and access Tirzepatide: FDA-approved as Mounjaro (May 2022) for type 2 diabetes FDA-approved as Zepbound (November 2023) for chronic weight management Available through retail pharmacy with prescription Available through Lilly Direct self-pay program ($499-$599/month for some vial doses) Available through 503A compounding pharmacies (status varies with FDA shortage designation) Insurance coverage: variable, with some plans covering Mounjaro for diabetes but not Zepbound for obesity Cagrilintide: Investigational, not FDA-approved as of May 2026 Available only through authorized clinical trials Not available through standard pharmacy channels Not approved for 503A compounding Gray-market suppliers offer products labeled as cagrilintide